See also Warning section. Hot flashes, nausea, leg cramps, muscle aches, hair thinning, headache, and numb/tingling skin may occur. A loss of sexual ability/interest may occur in tamoxifen reviews men. If these effects persist or worsen, notify your doctor promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: vision changes (e.g., blurred vision eye pain, easy bruising/bleeding, mental/mood changes, swelling of ankles /feet, unusual tiredness. Tell your doctor right away if any of these rare but very serious side effects occur: stomach / abdominal pain, persistent nausea / vomiting, dark urine, yellowing eyes /skin, signs of infection (e.g., fever, persistent sore throat ). A very serious allergic reaction to this drug is rare. However, seek immediate medical tamoxifen reviews attention if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/ tongue /throat severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at). Steroids are currently the only available treatment to reduce the repetitive cycles of inflammation and disease progression associated with functional deterioration in patients with muscular dystrophy (MD). A study reported in the. American Journal of Pathology showed that a new treatment approach using the selective estrogen receptor modulators (serms) tamoxifen and raloxifene significantly improved cardiac, respiratory, and skeletal muscle functions and increased bone density in both male and female mice with the same gene defects. "Our results show that there are two important advantages of tamoxifen and raloxifene treatment over steroids, which have limited benefits for patients with. First, the serms improve both histology and function of all muscles; although steroids improve histology, they improve function to a much lesser extent. Second, serms enhance bone density, whereas steroids exacerbate osteoporosis and increase the risk for fractures explained Qi Long Lu, MD, PhD, director of the McColl-Lockwood Laboratory for Muscular Dystrophy Research, tamoxifen reviews Neuromuscular/ALS Center, Department of Neurology, Atrium Health's (formerly Carolinas HealthCare System's) Carolinas Medical Center, Charlotte. The mice used in this study have the identical gene defects and show almost the same disease manifestation as patients with MD and are therefore an excellent model for therapeutic evaluation. Investigators administered tamoxifen (2, 10, or 50 mg/kg tamoxifen reviews raloxifene (50 or 100 mg/kg or saline to mutant mice with dystroglycanopathy, a form of MD, for up to a year, beginning at three weeks of age. The investigators found several indicators that tamoxifen and raloxifene delay or even halt disease progression. Within one month, treatment with either serm reduced muscle pathology with significant reduction in the numbers of degenerating fibers. After a year, control mice showed high variation in fiber size with focal inflammatory infiltrations, but these dystrophic changes were much less evident after tamoxifen or raloxifene. A noticeable reduction in collagen accumulation in limb muscles for all treatment groups vs controls was observed. Importantly, treatment with serms clearly mitigates muscle damage and enhances functions of both respiratory and cardiac muscles in addition to the limb muscles. Other benefits were also observed. Control mice showed progressive muscle degeneration and regeneration in the diaphragm, accompanied by increasing fibrosis and infiltration, as well as significant impairment in respiration. Both tamoxifen and raloxifene eliminated focal infiltration and reduced the extent of fibrosis in the diaphragm, increased mass, and improved breathing ability. "Both treatments also improved bone density in the tibia and femur, potentially reducing the risk of fracture, a major threat to patients as MD progresses added co-author Bo Wu, PhD, a research scientist at the McColl-Lockwood Laboratory for Muscular Dystrophy Research, Neuromuscular/ALS Center, Department. These histological changes were accompanied by functional improvements. For example, serm treatment improved grip strength of both forelimb and hindlimb muscles and enhanced running ability on a treadmill test depending on the dose. Sex-related differences in the effects of tamoxifen and raloxifene warrant careful consideration if the drugs are to be administered clinically for MD, noted the investigators. This is not surprising since serms act on estrogen receptors and interact both as estrogen-receptor agonists and antagonists.
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Tamoxifen 40 mg
Generic Name: tamoxifen (ta MOX i fen brand Names: Soltamox, medically reviewed on August 4, 2017. Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer tamoxifen 40 mg require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if tamoxifen 40 mg she has a high risk (such as a family history of breast cancer). Tamoxifen may also be used for purposes not listed in this medication guide. Do not use tamoxifen if tamoxifen 40 mg you are pregnant. It could harm the unborn baby. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months tamoxifen 40 mg after your treatment ends. You should not use tamoxifen if you are allergic to it, or if you have tamoxifen 40 mg a history of blood clots in your veins or your lungs, or if you are also taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation tamoxifen 40 mg treatment. If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking this medicine, to make sure you are not pregnant. Follow your doctor's instructions. Taking tamoxifen may increase your risk of uterine cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your specific risks in taking this medication. To make sure this medication is not causing harmful effects, your doctor may want you to have mammograms and to perform routine breast self exams on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly. Before taking this medicine, you should not use tamoxifen if you are allergic. You should not use tamoxifen to reduce your risk of breast cancer if you are also taking a blood thinner such as warfarin (Coumadin, Jantoven). Do not take tamoxifen if you are pregnant. Avoid becoming pregnant while you are using this medicine, and for at least 2 months after your treatment ends. Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while taking tamoxifen. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide, or intrauterine device/IUD). You may also need to have a pregnancy test before you start taking tamoxifen, to make sure you are not pregnant. Talk with your doctor about your specific risks in taking this medicine.
Does tamoxifen cause diarrhea
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